Featured Video

ARTISS use in a facelift procedure.

ARTISS [Solutions
for Sealant] use in
a facelift procedure.


Surgical Case

ARTISS use on a radial forearm burn.

ARTISS [Solutions
for Sealant] use on
a dorsal hand burn.


How ARTISS [Solutions for Sealant] Works

ARTISS [Solutions for Sealant] is comprised of two human plasma derived components:1

  • A sealer protein solution containing human fibrinogen and a synthetic fibrinolysis inhibitor that helps delay the premature breakdown of the clot at the site of application1
  • A low-concentration human thrombin solution in a calcium chloride solution, which allows an extended polymerization time of 60 seconds compared to other fibrin sealants that can contain 500 IU/mL or more of thrombin2,3

The adhesive properties of ARTISS [Solutions for Sealant] provide full surface adherence of the graft to the wound bed, closing the space that exists when grafts are attached using point fixation techniques such as staples.3,4

Learn how ARTISS [Solutions for Sealant] is custom-designed for plastic surgery

See more on the steps to prepare ARTISS [Solutions for Sealant] for use


  1. ARTISS [Solutions for Sealant]. Summary of Product Characteristics. Baxter International Inc: Vienna, Austria. October 2011.
  2. Gibran N, Luterman A, Herndon D, et al. Comparison of fibrin sealant and staples for attaching split-thickness autologous sheet grafts in patients with deep partial- or full-thickness burn wounds: a phase ½ clinical study. J Burn Care Res. 2007;28(3):401-8
  3. Foster K, Greenhalgh D, Gamelli RL, et al. FS 4IU VH S/D Clinical Group. Efficacy and safety of a fibrin sealant for adherence of autologous skin grafts to burn wounds: results of a phase 3 clinical study. J Burn Care Res. 2008;29(2):293-303.
  4. Rohrich RJ, Shire JR, Desmond JC, et al. ARTISS improves flap adherence following rhytidectomy through full surface adherence between the wound bed and applied tissue, which eliminates areas of dead space often associated with hematoma and seroma: results of a phase 3, multicenter, prospective, randomized, clinical study. Paper presented at: American Association of Plastic Surgeons (AAPS) 90th Annual Meeting; April 9-12, 2011; Boca Raton, Fla.