Mechanism of Action

See how ARTISS works.

See how ARTISS [Solutions for Sealant] works.

Play

Surgical Case

ARTISS use on a radial forearm burn.

ARTISS [Solutions
for Sealant] use on
a dorsal hand burn.

Play

ARTISS Resources

ARTISS use on a radial forearm burn.

Brochure–
Provides Time for the Finishing Touch

Provides Time for the Finishing Touch

ARTISS [Solutions for Sealant] – first and only fibrin sealant custom designed for subcutaneous tissue adherence in plastic surgery1

  • Allows up to 60 seconds to manipulate and position the flap1-3
  • Full surface adherence eliminating dead space2,3
  • Significantly reduces drainage volumes compared to standard of care2
  • May eliminate the need for surgical drains2
  • Reduces the incidence of hematoma and seroma compared to standard of care2,4,5
  • Frozen ready-to-use formulation—no mixing or diluting required4
  • Improved patient satisfaction4

Clinical Evidence

The safety and efficacy of ARTISS [Solutions for Sealant] was shown in a prospective, randomized, controlled, multicenter clinical phase 3 study involving 75 facial rhytidectomy procedures. The study used a split-face design to evaluate skin flap adherence and reduction of dead space between ARTISS and standard of care (SoC) vs. standard of care alone.

  • Total mean ± standard deviation of drainage volume at 24 ± 4 hr postsurgery ARTISS + SoC vs. SoC alone was: 7.7 ± 7.4 mL vs 20.0 ± 11.3 mL (p < 0.0001)2
  • On the ARTISS + SoC-treated sides, a total of 7 hematoma/seroma events occurred in 5 subjects vs. a total of 17 in 17 subjects on the SoC-treated sides5
  • Higher patient preference for the ARTISS-treated side compared to SoC-treated side, reporting better appearance at Day 1, 3, 7 and 14 post-operative with 63%, 53%, 59% and 57%, respectively6

Post-rhytidectomy bilateral drainage tube placement and treatment at day 12

ARTISS may allow for the elimination of drain placement in facial rhytidectomy (mean drainage volume ≤ 15 mL/side at 24 hr postsurgery)2

Preop appearance and face on postop day 1 after rhytidectomy with ARTISS1

Patient pictures taken from the study described in Rohrich RJ et al. All patients gave their written
consent to Baxter to use the pictures.

ARTISS Use in Facelift Surgery

This animation demonstrates a step-by-step overview of ARTISS [Solutions for Sealant] use for
a facelift.

James Shire, MD, FACS, demonstrates application of ARTISS [Solutions for Sealant] once the
flap has been approximated and trimmed and the wound is ready for closure.

Daniel Mills, MD, demonstrates an alternate technique in which he applies ARTISS [Solutions for
Sealant] and puts the flap into place prior to trimming the excess skin. Once ARTISS [Solutions
for Sealant] has polymerized, Dr. Mills then proceeds to suture and trim the excess skin, while
taking care not to disrupt or move the area in which ARTISS [Solutions for Sealant] has been
applied.

Learn how ARTISS [Solutions for Sealant] is custom-designed for burn surgery

See more on the steps to prepare ARTISS [Solutions for Sealant] for use

 

  1. Data on file. Westlake Village, Calif: Baxter Healthcare Corp.
  2. Rohrich RJ, Shire JR, Desmond JC, et al. ARTISS improves flap adherence following rhytidectomy through full surface adherence between the wound bed and applied tissue which eliminates areas of dead space often associated with hematoma and seroma: results of a phase 3, multicenter, prospective, randomized clinical study. Paper presented at : American Association of Plastic Surgeons (AAPS) 90th Annual Meeting, Boca Raton, FL, April 9-12, 2011.
  3. Foster K, Greenhalgh D, Gamelli RL, et al. FS 4IU VH S/D Clinical Study Group. Efficacy and safety of a fibrin sealant for adherence of autologous skin grafts to burn wounds: results of a phase 3 clinical study. J Burn Care Res. 2008; 29(2):293-303.
  4. ARTISS [Solutions for Sealant]. Summary of Product Characteristics. Baxter International Inc: Vienna, Austria. October 2011.
  5. Mustoe TA et al. Reduced hematoma/seroma occurrence with use of fibrin sealant during facial rhytidectomy: results of an integrated analysis of phase 2 and phase 3 study data. Oral presentation at ASPS Meeting 2011, Denver Colorado, Sept. 23-27.
  6. Hester TR et al. Qualitative comparison of patient and investigator preferences following the use of fibrin sealant to adhere tissues and improve wound healing in patients undergoing rhytidectomy. E-poster presentation at ASPS meeting 2011, Denver Colorado, Sept. 23-27.